The match will mark the start of the end of representative football for the great Darren Lockyer, with the 2011 series to be the last for one of Queensland's best ever players.
Not only will he be looking to lead his team to a record breaking 6th straight series win, but in Game 1 he will equal the great Allan Langer with 34 Origin Games.
His Queensland team mates will be desperate to send him out a winner, and a victory on home soil in Game 1 will go a long way to achieving that goal.
For the NSW boys, a few new faces have been called in to the squad as they look to win the opening game of a series for the first time since 2008.
Not only have their northern rivals dominated in the series count in recent years, they have also allowed NSW to win just 1 in the past 8 starts, so the Blues will be putting everything on the line to win in Brisbane.
Expect fast, entertaining and high scoring football, with the odd bit of biffo thrown in for good measure.
Make sure you don't miss a minute of the action - tune in to Grandstand Digital 1 or 2 this Wednesday night from 6:35pm
Get all your State of Origin news here
